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There is some overlap between the kits, as each kit tends to "build on" and incorporate experiments and materials from the previous kit. However, the safety glasses in the C1000 kit (and up) are still an improvement over the goggles in the C500 kit. With the introduction of the C500, the lab manual has been "overhauled," according to the manufacturer, to bring it up to speed with the other kits. In the past, we recommended the C1000 and up for most chemistry courses, as the lab manual for the first kit was skimpier on explanations, but now that the C101 has been replaced with the C500, this is no longer the case. If you're especially interested in chemistry, I would recommend the C1000 kits and up because they are more extensive in content and materials. I mean, performing chemistry experiments? Each kit provides just about everything you need to do experiments that take mere minutes to complete. What could be more fun than playing with bubbling mixtures and liquids that change color, err.
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